Fourteen novel α-(substituted pyrazol-4-carbonyloxy)-α-arylmethyl phosphonates 7a～7n were synthesized from the intermediates 5-chloro-3-trifluoromethyl-1-phenylpyrazol-4-carbonyl chloride (4) and α-hydroxyl-α-arylmethyl phos- phonates (6). All compounds synthesized were identified by 1H NMR, IR spectra and elemental analysis, and the structure of 7j was further determined by X-ray single crystal diffraction method. The preliminary bioassay indicated that some compounds showed moderate fungicidal and herbicidal activities.
Liang Ying
,
He Hongwu
,
He Haifeng
,
Yang Ziwen
. Synthesis, Crystal Structure and Biological Activity of α-(5-Chloro- 3-trifluoromethyl-1-phenylpyrazol-4-carbonyloxy)-α- arylmethyl Phosphonates[J]. Chinese Journal of Organic Chemistry, 2012
, 32(08)
: 1513
-1518
.
DOI: 10.6023/cjoc1201041
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