SIOC 中文
CJOG
Adv search

Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 9: 1746 - 1748

DOI: https://doi.org/10.6023/cjoc1201302

Notes

One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation

  • Yuan Mingyue ,
  • Liu Min ,
  • Zhang Yingqun ,
  • Yan Hongfei ,
  • Li Defu ,
  • Zhang Dongnuan ,
  • Liu Huimin
Expand
  • a College of Science, Agricultural University of Hebei, Baoding 071001;
    b College of Plant Protection, Agricultural University of Hebei, Baoding 071001

Received date: 2012-01-30

  Revised date: 2012-05-18

  Online published: 2012-04-24

Supported by

Project supported by the Foundation of Hebei Educational Committee (No.2009435) and the Non-life Disciplines and Emerging Disciplines Foundation of Hebei Agricultural University (No.2009020)

Fold

Abstract

An efficient one-pot method is used to prepare a series of 2-acetamide-thiazole derivatives from α-bromoketone, thiourea and acetic anhydride under microwave irradiation. The reaction procedures have the advantages of easy work up, short time and simple operation. The products were identified by 1H NMR and IR spectra and elemental analysis. These compounds exhibit good antimicrobial activities.

Key words： microwave irradiation; one-pot synthesis; 2-acetamide-thiazole derivatives; biological activity

Cite this article

Yuan Mingyue , Liu Min , Zhang Yingqun , Yan Hongfei , Li Defu , Zhang Dongnuan , Liu Huimin . One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, 2012 , 32(9) : 1746 -1748 . DOI: 10.6023/cjoc1201302

References

[1] Lin, Y. F.; Hu, W. X.; Yang, Z. Y.; Wang, L. G. J. Zhejiang Univ. Technol. 2007, 35, 27 (in chinese). (林燕芳, 胡惟孝, 杨忠愚, 王列岗, 浙江工业大学学报, 2007, 35, 27.)

[2] Yuan, M. Y.; Zhang, D. N.; Yan, H. F.; Liu, W. H.; Li, D. F.; Zhang, Y. Q. Chin. J. Org. Chem. 2011, 31, 1930 (in Chinese). (袁明月, 张冬暧, 闫红飞, 刘伟华, 李德富, 张英群, 有机化学, 2011, 31, 1930.)

[3] Luo, X. Y.; Ren, Y. G.; Huang, M. Z. Pestic. Res. Appl. 2006, 10, 5 (in Chinese). (罗晓艳, 任叶果, 黄明智, 农药研究与应用, 2006, 10, 5.)

[4] Sun, X. J.; Zhou, J. F. J. Anhui Agric. Sci. 2008, 36, 14389 (in Chinese). (孙小军, 周建峰, 安徽农业科学, 2008, 36, 14389.)

[5] Hassan, H. M.; Kora, F. A.; El-Haddad, A. F.; El-Naggar, A. M.; Abdel-Kader, M. Acta Pharm. 1997, 47, 159.

[6] Panhekar, D. Y.; Ghiya, B. J. Indian J. Heterocycl. Chem. 1995, 5, 159.

[7] Trivedi, V.; Rao, J. T. J. Inst. Chem. 1997, 69, 75.

[8] King, L. C.; Hlavacek, R. J. J. Am. Chem. Soc. 1950, 72, 3722.

[9] Bonilla, P. M.; Cardena, A. P.; Marmol, E. Q.; Tellez, L. A.; Mena, G. J. Heteroat. Chem. 2006, 17, 254.

[10] Ramanna, S.; Rajeswar, R. V.; Surya, K. T.; Padmanabha, R. T. V. Phosphorus, Sulfur Silicon Relat. Elem. 1995, 107, 197.  

Options
Outlines

/

〈 〉