Reviews

Research Progress in the Prodrugs of Curcumin

  • Tu Yongyuan ,
  • Xu Xianxiang ,
  • Qiu Fei
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  • a Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021;
    b Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou 362021

Received date: 2011-07-22

  Revised date: 2011-11-02

  Online published: 2011-12-12

Supported by

Project supported by the National Natural Science Foundation of China (No. 30900351), the Natural Science Foundation of Fujian Province of China (No. 2009J05029), the Fujian Biomedicial Engineering Graduate Student’s Educational Innovation Base (No. 06070205) and the Scientific Research Foundation of Huaqiao University (No. 08BS412).

Abstract

In recent years, curcumin, a natural product, has been drawing attention from researchers for it has many kinds of significant bioactivities, such as antitumor activity. However, its clinical utility is limited due to a number of undesirable difficulties, such as its low aqueous solubility, instability and low bioavailability. Through conjugated the phenolic hydroxyl group of curcumin with low or high molecular weight carriers, various prodrugs of curcumin have been studied and developed to overcome its disadvantages. The development of prodrugs of curcumin was an effective method to improve the druggability of curcumin. In this paper, the research progresses in the prodrugs of curcumin in recent years are reviewed.

Cite this article

Tu Yongyuan , Xu Xianxiang , Qiu Fei . Research Progress in the Prodrugs of Curcumin[J]. Chinese Journal of Organic Chemistry, 2012 , 32(05) : 852 -859 . DOI: 10.6023/cjoc1107221

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