Reviews

Palladium-Catalyzed Suzuki Reaction in Aqueous Media

  • Liu Ning ,
  • Liu Chun ,
  • Jin Zilin
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  • State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024

Received date: 2011-09-05

  Revised date: 2011-11-04

  Online published: 2011-12-09

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20976024, 21076034) and the Special Research Foundation of Dalian University of Technology for Retired Professors (No. DUTTX 2011103).

Abstract

The palladium-catalyzed Suzuki cross-coupling reaction has become one of the most powerful tools for sp2-sp2 carbon-carbon bond formation. This coupling reaction is increasingly being applied in the synthesis of pharmaceuticals, natural products and advanced functional materials. In recent years, developing aqueous systems for the Suzuki reaction has attracted attention from many researchers. This paper reviews the recent progress in the Suzuki reaction using neat water and aqueous-organic co-solvent as reaction media. A large number of different strategies for the Suzuki reaction in water have been developed, in which the authors aim at the solutions to the enhancement of the reactivity of the palladium-catalyzed Suzuki reaction using water-soluble ligands, surfactants, microwave assistance, or ligand-free system.

Cite this article

Liu Ning , Liu Chun , Jin Zilin . Palladium-Catalyzed Suzuki Reaction in Aqueous Media[J]. Chinese Journal of Organic Chemistry, 2012 , 32(05) : 860 -876 . DOI: 10.6023/cjoc1109052

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