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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 05: 877 - 888

DOI: https://doi.org/10.6023/cjoc1107132

Reviews

Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors

  • Huang Shaoxu ,
  • Wang Yong ,
  • Long Yaqiu
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  • Laboratory of Medicinal Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203

Received date: 2011-07-13

  Revised date: 2011-11-17

  Online published: 2011-12-07

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 81021062, 81072527).

Fold

Abstract

Hypertension is a common illness nowadays. Although a wide variety of antihypertensive agents are available in the market for the treatment of hypertension, the antihypertensive treatment tends to be individualized, and the treatment should exceed the limitation of lowering blood pressure only. Compared to other antihypertensive agents, the advantage of human soluble epoxide hydrolase inhibitors (HsEHIs) is that they can not only reduce the blood pressure, but also have remarkable anti-inflammatory effects. Herein, the development of human soluble epoxide hydrolase inhibitors is reviewed from early epoxide HsEHIs to the third generation of urea HsEHIs.

Key words： soluble epoxide hydrolase; epoxyeicosatrienoic acid; inhibitors; 1,3-disubstituted urea; hypertension; inflammation

Cite this article

Huang Shaoxu , Wang Yong , Long Yaqiu . Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors[J]. Chinese Journal of Organic Chemistry, 2012 , 32(05) : 877 -888 . DOI: 10.6023/cjoc1107132

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