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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 10: 1999 - 2002

DOI: https://doi.org/10.6023/cjoc201204004

Notes

A Facile and Efficient Synthesis of Polysubstituted Cyclohexanol Derivatives under Solvent-Free Conditions

  • Rong Liangce ,
  • Wei Xianyong ,
  • Lu Yao ,
  • Zong Zhimin
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  • a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received date: 2012-04-05

  Revised date: 2012-05-15

  Online published: 2012-06-04

Supported by

Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Foundation of Xuzhou Normal University (No. 10XLS02).

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Abstract

A facile and efficient synthesis of polysubstituted cyclohexanol derivatives by the addition and cyclization reaction of substituted acetophenone and chalcone in the presence of NaOH under solvent-free conditions is reported. This protocol has the advantages of shorter reaction time, mild conditions, easy work-up, and environmental friendliness. The products were identified by IR, 1H NMR and elemental analysis. The solvent-free method is the efficient approach for the synthesis of these compounds.

Key words： chalcone; cyclohexanol; solvent-free reaction; Michael addition; aldol condensations

Cite this article

Rong Liangce , Wei Xianyong , Lu Yao , Zong Zhimin . A Facile and Efficient Synthesis of Polysubstituted Cyclohexanol Derivatives under Solvent-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2012 , 32(10) : 1999 -2002 . DOI: 10.6023/cjoc201204004

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