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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 10: 1880 - 1887

DOI: https://doi.org/10.6023/cjoc1112303

Articles

Synthesis of 6-Amino-purine Derivatives Catalyzed by Polyethylene Glycol1000-Dicationic Acidic Ionic Liquid

  • Lu Hongfei ,
  • Sun Leilei ,
  • Wu Dingming ,
  • Gao Yuhua ,
  • Shi Yali ,
  • Xue Qin
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  • School of Biological and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003

Received date: 2011-12-30

  Revised date: 2012-05-29

  Online published: 2012-06-12

Supported by

Project supported by the Technological Innovation to Science and Technology Enterprises in Jiangsu Province (No. BC2011451).

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Abstract

A series of 6-amino-purine derivatives were synthesized from 4,6-dichloro-5-pyrimidine via three step reactions: N-alkylation, cyclization and N-alkylation of purine. All the reactions were catalyzed by the polyethylene glycol1000-dicationic acidic ionic liquid (PEG1000-DAIL). Compared to other synthetic methods, this method not only enhanced the yield, but also avoided the hydrolysis of the chloride to the hydroxyl group during the cyclization. The product can be isolated easily and the catalytic system can be recycled and reused for subsequent reactions.

Key words： purine derivatives; pyrimidine; polyethylene glycol1000-dicationic acidic ionic liquid; N-alkylation

Cite this article

Lu Hongfei , Sun Leilei , Wu Dingming , Gao Yuhua , Shi Yali , Xue Qin . Synthesis of 6-Amino-purine Derivatives Catalyzed by Polyethylene Glycol1000-Dicationic Acidic Ionic Liquid[J]. Chinese Journal of Organic Chemistry, 2012 , 32(10) : 1880 -1887 . DOI: 10.6023/cjoc1112303

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