Articles

Synthesis and Antitumor Activities of Novel 1,2,3-Triazole-fused Oligoconjugates Based on Nucleoside and Saccharide

  • Jin Peiyuan ,
  • Lu Jinrong ,
  • Zhao Changqi ,
  • Ju Yong
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  • a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084;
    b School of Life Science, Beijing Normal University, Beijing 100875;
    c State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 73000

Received date: 2012-05-25

  Revised date: 2012-07-02

  Online published: 2012-06-21

Supported by

Project supported by the National Natural Science Foundation of China (No.21172130) and the National Program on Key Basic Research Project (973 Program) (No.2012CB821600)

Abstract

Novel 1,2,3-triazole-fused oligoconjugates 7~12 based on nucleoside and saccharide were synthesized via click chemistry. The structures were confirmed by 1H NMR and MS, and their antitumor activities were assayed against cervix cancer HeLa cells in vitro. The preliminary bioassay test shows that only bis(triazole) nucleoside 11a considerably inhibited the growth of cervix cancer HeLa cells and was much better than azidothymidine.

Cite this article

Jin Peiyuan , Lu Jinrong , Zhao Changqi , Ju Yong . Synthesis and Antitumor Activities of Novel 1,2,3-Triazole-fused Oligoconjugates Based on Nucleoside and Saccharide[J]. Chinese Journal of Organic Chemistry, 2012 , 32(9) : 1673 -1677 . DOI: 10.6023/cjoc201205031

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