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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 11: 2187 - 2192

DOI: https://doi.org/10.6023/cjoc201206006

Notes

Synthesis and Preliminary Anticancer Activity Evaluation of Tetrahydropyrido[4,3-d]dihydropyrimidine-2-one Derivatives

  • Wang Jing ,
  • Ding Li ,
  • Xiao Di ,
  • Xue Sijia
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  • College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234

Received date: 2012-06-06

  Revised date: 2012-06-27

  Online published: 2012-07-04

Supported by

Project supported by the Key Scientific “Twelfth Five-Year” National Technology Support Program (No. 2011BAE06B01-17), and the National Natural Science Foundation of China (Nos. 21042010, 21102092, 30870560).

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Abstract

In search of more effective anticancer agents, sixteen novel tetrahydropyrido[4,3-d]dihydropyrimidine-2-one derivatives 2a～2p were synthesized by reacting N-(4-substituted benzyl)-3,5-bisbenzylidene-4-piperidone with urea in EtONa/EtOH under reflux condition. The structures were confirmed by 1H NMR, IR, MS and elemental analysis. The preliminary bioassay indicated that some title compounds exhibited good antiproliferative activities against K562 cells, certain antiproliferative activities against ovarian cancer HO-8910 cells and liver cancer SMMC-7721 cells.

Key words： tetrahydropyrido[4,3-d]dihydropyrimidine-2-one; derivative; synthesis; leukemic K562 cells; anticancer activities

Cite this article

Wang Jing , Ding Li , Xiao Di , Xue Sijia . Synthesis and Preliminary Anticancer Activity Evaluation of Tetrahydropyrido[4,3-d]dihydropyrimidine-2-one Derivatives[J]. Chinese Journal of Organic Chemistry, 2012 , 32(11) : 2187 -2192 . DOI: 10.6023/cjoc201206006

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