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Enantioselective Conjugate Addition of Diethylzinc to Vinylogous Imines Generated in situ from Sulfonyl Indoles
Received date: 2012-07-07
Revised date: 2012-08-02
Online published: 2012-08-06
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21102116, 20772097).
Enantioselective conjugate addition of diethyl zinc to vinylogous imines generated in situ from sulfonyl indoles was developed. Various sulfonyl indoles reacted with diethyl zinc in the presence of chiral phosphoramidites in combination with copper triflate affording the corresponding indole substituted alkanes in up to 99% yield with moderate to good enantioselectivity (up to 80% ee).
Ni Chengyan , Li Wenke , He Long , Liu Quanzhong , Kang Tairan . Enantioselective Conjugate Addition of Diethylzinc to Vinylogous Imines Generated in situ from Sulfonyl Indoles[J]. Chinese Journal of Organic Chemistry, 2012 , 32(12) : 2322 -2327 . DOI: 10.6023/cjoc201207011
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