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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 12: 2378 - 2381

DOI: https://doi.org/10.6023/cjoc201205025

Notes

Application of Microwave Technique into Etherification of 10-Hydroxycamptothecin

  • Meng Guangrong ,
  • Li Jiajun ,
  • Zhang Qian ,
  • Ma Hongmei
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  • a Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203;
    b School of Pharmacy, East China University of Science & Technology, Shanghai 200237

Received date: 2012-05-19

  Revised date: 2012-08-01

  Online published: 2012-08-10

Supported by

Project supported by the National Drug Innovative Program (No. 2009ZX09301-011).

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Abstract

In an effort to reduce the cleavage of E lactone ring in camptothecin, microwave technique was applied in the etherification of 10-hydroxycamptothecin. Compared with the conventional heating condition, microwave can truncate the reaction time and improve the yield from 20%～30% to 50%～83% significantly. Furthermore, this reaction condition could be used for reference in other relative reactions of camptothecins.

Key words： 10-hydroxycamptothecin; etherification; microwave technology

Cite this article

Meng Guangrong , Li Jiajun , Zhang Qian , Ma Hongmei . Application of Microwave Technique into Etherification of 10-Hydroxycamptothecin[J]. Chinese Journal of Organic Chemistry, 2012 , 32(12) : 2378 -2381 . DOI: 10.6023/cjoc201205025

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