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Chinese Journal of Organic Chemistry >

2012 , Vol. 32 >Issue 12: 2358 - 2362

DOI: https://doi.org/10.6023/cjoc201207047

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Convenient Synthesis and Characterization of Hydrazone Derivatives of 3-(2-Naphthyl)-1-phenyl-pyrazole-4-carbaldehyde

  • Ablajan Keyume ,
  • Wang Liju
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  • Key Laboratory of Oil & Gas Fine Chemical, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Received date: 2012-07-31

  Revised date: 2012-08-15

  Online published: 2012-08-22

Supported by

Project supported by the Natural Science Foundation of Xinjiang Uyghur Autonomous Region (No. 2009211A02).

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Abstract

In order to obtain novel hydrazone derivatives containing pyrazole and thiazole rings which possess certain biological activity, a series of 1-(3-β-naphthyl-1-phenylpyrazole-4-methylene)-2-(4-arylthiazol-2-yl)hydrazones were synthesized via two different methods including multi step reactions and one-pot synthetic route using 3-β-naphthyl-1-phenyl-pyra- zole-4-carbaldehyde as a starting intermediate. The products were obtained in good yield under ultrasonic irradiation condition rather than heating. The structures of products were characterized by 1H NMR, MS and elemental analysis. The preliminary bioassay showed that compounds 4b and 4d possess obvious protective effects on the PC12 cells injury induced by H2O2.

Key words： pyrazole; thiazole; hydrazone; synthesis; ultrasonic irradiation; one-pot reaction

Cite this article

Ablajan Keyume , Wang Liju . Convenient Synthesis and Characterization of Hydrazone Derivatives of 3-(2-Naphthyl)-1-phenyl-pyrazole-4-carbaldehyde[J]. Chinese Journal of Organic Chemistry, 2012 , 32(12) : 2358 -2362 . DOI: 10.6023/cjoc201207047

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