Chinese Journal of Organic Chemistry >
Synthesis and Antiproliferatory Activity of Novel Diphyllin Hydroxamic Acid and Mercaptan Derivatives
Received date: 2012-08-31
Revised date: 2012-09-24
Online published: 2012-10-09
Supported by
Project supported by the Natural Science Foundation of Jiangsu Province (No. BK2011390) and the Priority Academic Program Development of Jiangsu Higher Education Instititutions (PAPD).
Seven novel diphyllin derivatives have been synthesized by incorporating histone deacetylase inhibitory functional groups into diphyllin. The structures were confirmed by 1H NMR, 13C NMR and HRMS. Their antiproliferative activity against three human cancer cell lines was investigated by methyl thiazolyl tetrazoliym (MTT) assay.
Key words： diphyllin; histone deacetylase inhibitors; antitumor; synthesis
Zhao Yu , Ni Chunyan , Zhang Yuting , Zhu Li . Synthesis and Antiproliferatory Activity of Novel Diphyllin Hydroxamic Acid and Mercaptan Derivatives[J]. Chinese Journal of Organic Chemistry, 2013 , 33(01) : 169 -173 . DOI: 10.6023/cjoc201208037
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