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Synthesis and Antibacterial Activity of 5-(2-Hydroxyphenyl)-1,3,4- thiadiazol-2-yl-sulfanyl Acetyl Hydrazones

  • Wang Yinghong ,
  • Yang Lu ,
  • Liu Zhichang
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  • Department of Chemistry, Leshan Normal University, Leshan 614000

Received date: 2012-06-12

  Revised date: 2012-10-08

  Online published: 2012-10-12

Supported by

Project supported by the Application of Basic Project of the Science and Technology Agency of Sichuan Province (No. 2010JY0148) and the Key Projects of the Science and the Technology Bureau of Leshan City in Sichuan Province (No. 08SZD092).

Abstract

A series of 5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazones were synthesized with 2-mercapto-5-(2-hydroxyphenyl)-1,3,4-thiadiazole as starting material, followed by thioetherification, hydrazide reaction and hydrazone reaction. The structures of these compounds were characterized by 1H NMR, 13C NMR, IR, MS techniques and elemental analysis. The antimicrobial activities of these compounds were also originally studied. The results showed that most of these compounds have potent antibacterial activities. These compounds of aromatic aldehyde-5-(2-hydroxyphen-yl)-1,3,4- thiadiazol-2-yl-sulfanyl acetyl hydrazone (4a4h) showed better antibacterial activities than 2-butenal-5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazone (4i).

Cite this article

Wang Yinghong , Yang Lu , Liu Zhichang . Synthesis and Antibacterial Activity of 5-(2-Hydroxyphenyl)-1,3,4- thiadiazol-2-yl-sulfanyl Acetyl Hydrazones[J]. Chinese Journal of Organic Chemistry, 2013 , 33(01) : 154 -158 . DOI: 10.6023/cjoc201206013

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