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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 01: 106 - 109

DOI: https://doi.org/10.6023/cjoc201209019

Articles

Synthesis of 8-Pentyl-guanosine by Direct Glycosylation

  • Huang Muhua
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  • School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081

Received date: 2012-09-13

  Revised date: 2012-10-09

  Online published: 2012-10-12

Supported by

Project supported by the National Natural Science Foundation of China (No. 21202008).

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Abstract

8-Pentyl-guanosine was prepared by direct glycosylation based on the easy access to 8-pentyl-guanine, which provided a green chemistry approach to 8-C-substituted guanosine. In addition, this paper reported the isolation and characterization of an iminophosphane intermediate, which provide an experimental evidence for the proposed mechanism.

Key words： 8-alkyl-guanine; direct glycosylation; nitrosopyrimdine; iminophosphane; nucleoside

Cite this article

Huang Muhua . Synthesis of 8-Pentyl-guanosine by Direct Glycosylation[J]. Chinese Journal of Organic Chemistry, 2013 , 33(01) : 106 -109 . DOI: 10.6023/cjoc201209019

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