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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 02: 353 - 358

DOI: https://doi.org/10.6023/cjoc201208033

Articles

Synthesis and Fungicidal Activities of 2-Benzylthio(sulfonyl)-5- methyl-7-substituted benzyloxy-1,2,4-triazolo[1,5-a] pyrimidine Derivatives

  • Lin Xuanfu ,
  • Tan Zan ,
  • Liu Yong ,
  • He Yinju ,
  • Bao Xiaoping
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  • Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025

Received date: 2012-08-29

  Revised date: 2012-10-15

  Online published: 2012-10-24

Supported by

Project supported by the Governor’s Foundation for Excellent Talents of Science, Technology & Education of Guizhou Province (No. 200817).

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Abstract

Using 2-benzylthio-5-methyl-7-hydroxyl-1,2,4-triazolo[1,5-a]pyrimidine as starting material, twelve novel 2-benzylthio-5-methyl-7-substituted benzyloxy-1,2,4-triazolo[1,5-a]pyrimidine derivatives 5a～5l and their sulfonyl analogues 6a～6l were synthesized through sequential reactions of etherification and oxidation, respectively. Their structures were characterized by 1H NMR, IR, MS and elemental analysis. The preliminary bioassay indicated that some compounds exhibited certain fungicidal activities, for example, the inhibition rates of compounds 5c, 5k and 5l (50 μg/mL) against Botrytis cinerea were 61%, 69% and 85%, respectively.

Key words： 1,2,4-triazolo[1,5-a]pyrimidine; thioether (sulfone); oxygen ether; synthesis; fungicidal activity

Cite this article

Lin Xuanfu , Tan Zan , Liu Yong , He Yinju , Bao Xiaoping . Synthesis and Fungicidal Activities of 2-Benzylthio(sulfonyl)-5- methyl-7-substituted benzyloxy-1,2,4-triazolo[1,5-a] pyrimidine Derivatives[J]. Chinese Journal of Organic Chemistry, 2013 , 33(02) : 353 -358 . DOI: 10.6023/cjoc201208033

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