Reviews

Recent Research Progress in Anticancer Alkaloid Lamellarin N and Lamellarin L

  • Wang Ailing ,
  • Zhao Zhuangzhi ,
  • Zheng Xuefang ,
  • Cao Hongyu
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  • a College of Environment and Chemical Engineering, Dalian University, Dalian 116622;
    b Liaoning Key Laboratory of Bio-organic Chemistry, Dalian University, Dalian 116622;
    c College of Bioengineering, Dalian University, Dalian 116622;
    d College of Agronomy, Northeast Agricultural University, Harbin 150030

Received date: 2012-09-24

  Revised date: 2012-10-16

  Online published: 2012-10-26

Supported by

Project supported by the National Natural Science Foundation of China (No. 20871024), the Talents Training Plan of Liaoning Province (No. RC-04-10) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).

Abstract

Lamellarins, a family of hexacyclic pyrrole alkaloids, originally isolated from marine invertebrates, display promising activities. The lamellarin N (LMN) is a member of the lamenllarin compounds. LMN exhibits a significant cytotoxicity against a large panel of cancer cell lines and potent inhibitors of various protein kinases which is better than lamellarin D (LMD). LMN and lamellarin L (LML) are similar in structure and activity. Therefore, the isolation, synthesis, biological activity and anti-cancer activity mechanism of LMN and LML are summarized.

Cite this article

Wang Ailing , Zhao Zhuangzhi , Zheng Xuefang , Cao Hongyu . Recent Research Progress in Anticancer Alkaloid Lamellarin N and Lamellarin L[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 483 -491 . DOI: 10.6023/cjoc201209034

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