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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 03: 648 - 651

DOI: https://doi.org/10.6023/cjoc201210014

Notes

A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives

  • Rong Liangce ,
  • Wei Xianyong ,
  • Zong Zhimin ,
  • Han Xiao ,
  • Zhang Chengyi ,
  • Shen Xiaofeng ,
  • Chen Xiang
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  • a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received date: 2012-10-12

  Revised date: 2012-11-21

  Online published: 2012-11-26

Supported by

Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017), the Foundation of Xuzhou Normal University (No. 10XLS02), and the Foundation from National Natural Science Foundation of China for Innovative Research Group (No. 50921002).

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Abstract

A facile and efficient synthesis of novel 2-amino-6-methyl-4-aryltetrahydronaphthalene derivatives by the reaction of aromatic aldehydes, 4-methylcyclohexanone, and malononitrile in the presence of NaOH and 95% EtOH is reported. This protocol has the advantages of shorter reaction time, mild conditions, and easy work-up. The products were identified by 1H NMR, IR and HRMS techniques. The reported method is the efficient approach for the synthesis of these compounds.

Key words： tetrahydronaphthalene; 4-methylcyclohexanone; malononitrile; multicomponent reaction

Cite this article

Rong Liangce , Wei Xianyong , Zong Zhimin , Han Xiao , Zhang Chengyi , Shen Xiaofeng , Chen Xiang . A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 648 -651 . DOI: 10.6023/cjoc201210014

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