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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 03: 607 - 610

DOI: https://doi.org/10.6023/cjoc201210032

Articles

A Novel Synthetic Method for 1-(2,4-Dichlorophenyl)-4-methyl- 5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic Acid

  • Yang Zhao ,
  • Wang Zhixiang ,
  • Fang Zheng ,
  • Guo Kai
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  • a College of Pharmacy, China Pharmaceutical of University, Nanjing 210009;
    b School of Pharmaceutical Science, Nanjing University of Technology, Nanjing 210009

Received date: 2012-10-17

  Revised date: 2012-11-23

  Online published: 2012-11-26

Supported by

Project supported by the National Key Basic Research Program of China (973 Program) (Nos. 2012CB725204, 2012CB721104).

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Abstract

A novel method for the synthesis of 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carbox- ylic acid was reported. The target compound was prepared starting from 4-chlorobenzaldehyde, which is inexpensive and easily available starting material, via adol condensation, cyclization and oxidation with the total yield of 50.6%. The structures of intermediates and final product were determined by 1H NMR and MS. The novel method with the advantages of shorten process, easily conducted procedure and relatively high yield is suitable for scale-up production.

Key words： 1,5-diarylpyrazole; phenyl hydrazone; cyclization; oxidation; synthesis

Cite this article

Yang Zhao , Wang Zhixiang , Fang Zheng , Guo Kai . A Novel Synthetic Method for 1-(2,4-Dichlorophenyl)-4-methyl- 5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic Acid[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 607 -610 . DOI: 10.6023/cjoc201210032

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