Chinese Journal of Organic Chemistry >
A Novel Synthetic Method of 5-Aminolevulinic Acid Hydrochloride
Received date: 2012-10-07
Revised date: 2012-12-04
Online published: 2012-12-07
In this paper, a novel synthetic method of 5-aminolevulinic acid (5-ALA) hydrochloride was described starting from cheap and easily available epichlorohydrin. The 5-aminolevulinic acid hydrochloride was obtained by Gabriel reaction, ring-opening, oxidation, substitution and hydrolysis. The results showed that the synthetic method has the advantages of materials being simply available, good overall yield, easily work-up and low cost.
Key words： epichlorohydrin; 5-aminolevulinic acid hydrochloride; synthesis
Chi Pengli , Xie Cuiyue , Lin Jimao . A Novel Synthetic Method of 5-Aminolevulinic Acid Hydrochloride[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 640 -642 . DOI: 10.6023/cjoc201210005
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