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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 03: 573 - 580

DOI: https://doi.org/10.6023/cjoc201211033

Articles

Functionalized Graphene Oxide as a Nanocarrier for Loading and Delivering of Oridonin

  • Xu Zhiyuan ,
  • Li Yongjun ,
  • Shi Ping ,
  • Wang Bochan ,
  • Huang Xiaoyu
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  • a School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237;
    b The State Key Laboratory of Bioreactor Engineering, Shanghai 200237;
    c Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    d State Key Laboratory of Molecular Engineering of Polymers (Fudan University), Shanghai 200043

Received date: 2012-11-16

  Revised date: 2012-12-01

  Online published: 2012-12-07

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 31100549, 21204098), the Shanghai Rising Star Program (No. 11QH1402800), and the Shanghai Scientific and Technological Innovation Project (No. 10431903000).

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Abstract

Graphene oxide (GO) was prepared by modified Hummers method firstly. In order to improve its water solubility and biocompatibility, 6-armed PEG was grafted onto GO via an amidation process. The size of GO-PEG was less than 250 nm and stability test indicated excellent dispersibility of GO-PEG in water and PBS buffer. Furthermore, oridonin, a widely used cancer chemotherapy drug, is adsorbed onto GO-PEG via blending. The drug loading ratio was determined to be as high as 105%, which was much higher than other common drug carriers. A549 lung cancer cell and MCF-7 breast cancer cell were chosen to study the cytotoxicity of GO-PEG/oridonin, GO-PEG, and free oridonin. The results demonstrated that GO-PEG did not show obvious toxicity (relative cell viability＞85%), even cultivated for 48 h at a relatively high concentration of 100 mg/L. Compared to oridonin, the GO-PEG/oridonin nanocarrier shows higher cytotoxicity in A549 and MCF-7 cells.

Key words： graphene oxide; oridonin; drug delivery

Cite this article

Xu Zhiyuan , Li Yongjun , Shi Ping , Wang Bochan , Huang Xiaoyu . Functionalized Graphene Oxide as a Nanocarrier for Loading and Delivering of Oridonin[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 573 -580 . DOI: 10.6023/cjoc201211033

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