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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 03: 562 - 567

DOI: https://doi.org/10.6023/cjoc201211020

Articles

Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine

  • Lu Zhou ,
  • Liu Chaoxiang ,
  • Yu Xing ,
  • Lin Zhongxiang
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  • College of Chemical Engineering Nanjing Forestry University, Nanjing 210037

Received date: 2012-11-09

  Revised date: 2012-12-06

  Online published: 2012-12-10

Supported by

Project supported by the National Natural Science Foundation of China (No. 31170536) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Abstract

A series of novel derivatives of dehydroabietylamine were synthesized by introducing some groups with good free radical scavenging activities into the dehydroabietylamine, such as hydrazone, gallic acid, oxime and isoniazid. Structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, MS and HRMS techniques. All the compounds were tested the ability on scavenging superoxide anion radical (O2-) and 1,1-dipheny-2-picrylhydrazyl (DPPH·). The results indicate that the inhibitory rate of O2- by (6) (38.18%) is twice as much as that of Vc (18.35%), and its capacity on scavenging DPPH· (IC50＝0.002×103 mg/L) is much better than Vc (IC50＝0.236×103 mg/L.

Key words： dehydroabietylamine; anti-free radical; acylhydrazone; gallic acid

Cite this article

Lu Zhou , Liu Chaoxiang , Yu Xing , Lin Zhongxiang . Synthesis and Anti-free Radical Activities of Several Novel Derivatives of Dehydroabietylamine[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 562 -567 . DOI: 10.6023/cjoc201211020

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