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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 03: 630 - 633

DOI: https://doi.org/10.6023/cjoc201210038

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A Practical Synthesis of 3-{[4-(2,6-Dichlorophenyl)piperidin-1-yl]- methyl}-2-(thiophen-2-yl)-1H-indole as a New Ligand for Opioid Receptor Like 1 Receptor

  • Cheng Yinan ,
  • Xie Guiying ,
  • Sun Shujun ,
  • You Xiufeng
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  • Plant Protection College, Henan Agricultural University, Zhengzhou 450002

Received date: 2012-10-19

  Revised date: 2012-12-05

  Online published: 2012-12-20

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Abstract

3-{[4-(2,6-Dichlorophenyl)piperidin-1-yl]methyl}-2-(thiophen-2-yl)-1H-indole (1) as a ligand for opioid receptor like 1 receptor was prepared via four steps from commercially available phenylhydrazine (2), 1-(thiophen-2-yl)- ethanone (3), 2,6-dichloro- phenyl-boronic acid (5) and 4-bromopyridine (6). This convenient approach was green and had potential application for the scale production because of recoverable reaction medium, simple isolating process of intermedi-ates, little waste and highly total yield of 65%.

Key words： substituted indole; synthesis; catalytic hydrogenation; condensation

Cite this article

Cheng Yinan , Xie Guiying , Sun Shujun , You Xiufeng . A Practical Synthesis of 3-{[4-(2,6-Dichlorophenyl)piperidin-1-yl]- methyl}-2-(thiophen-2-yl)-1H-indole as a New Ligand for Opioid Receptor Like 1 Receptor[J]. Chinese Journal of Organic Chemistry, 2013 , 33(03) : 630 -633 . DOI: 10.6023/cjoc201210038

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