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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1263 - 1272

DOI: https://doi.org/10.6023/cjoc201209028

Reviews

Progress in Synthesis and Antagonistic Activities towards PAFR and GlyR of Ginkgolide Derivatives and Analogs

  • Hui Ailing ,
  • Wu Zeyu ,
  • Yuan Yuan ,
  • Zhou An ,
  • Pan Jian
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  • a Institute of Natural Medicine, Hefei University of Technology, Hefei 230009;
    b Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038

Received date: 2012-09-20

  Revised date: 2012-12-19

  Online published: 2012-12-25

Supported by

Project supported by the Science and Technology Project of Anhui Province (No.11010401025).

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Abstract

Ginkgolides are diterpene trilactones with a cage-like skeleton consisting of six five-membered rings and a unique t-Bu group from Ginkgo biloba tree.Many studies have demonstrated that they are highly potent and selective antagonists of platelet activating factor receptor (PAFR) and glycine receptor (GlyR).Ginkgolide skeleton modifications may conduce to physiological activities variation.Therefore, many ginkgolide derivatives and analogs have been synthesized for the optimal antagonistic activities towards PAFR or GlyR.This review covers the structure-activity relationship studies of ginkgolide derivatives and analogs.

Key words： ginkgolide derivatives; ginkgolide analogs; platelet activating factor receptor; glycine receptor; structure-activity relationship

Cite this article

Hui Ailing , Wu Zeyu , Yuan Yuan , Zhou An , Pan Jian . Progress in Synthesis and Antagonistic Activities towards PAFR and GlyR of Ginkgolide Derivatives and Analogs[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1263 -1272 . DOI: 10.6023/cjoc201209028

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