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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 05: 1074 - 1079

DOI: https://doi.org/10.6023/cjoc201210020

Articles

Synthesis and Antimicrobial Evaluation of Novel Pyrimidoquinolines

  • Chen Yu ,
  • Bai Shun ,
  • Ai Yong ,
  • Fan Hua ,
  • Yang Guangzhong
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  • a College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074;
    b College of Pharmacy, South-Central University for Nationalities, Wuhan 430074

Received date: 2012-10-13

  Revised date: 2012-12-16

  Online published: 2013-01-04

Supported by

Project supported by the National Key Technology R&D Program in the 12th Five Year Plan of China (No. 2012BAI27B06).

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Abstract

A facile and efficient approach was adopted for the synthesis of a series of novel pyrimido[5,4- c]quinolin-4(3H)-one derivatives. All the synthesized compounds were characterized using spectroscopic data (IR, 1H NMR, and mass spectrometry) and evaluated for their in vitro antimicrobial activities against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Escherichia coli) as well as fungi (Canibia albican) by broth microdilution method. The antimicrobial screening revealed that the tested compounds showed slightly to moderate antibacterial and antifungal activities.

Key words： pyrimidoquinoline derivative; antimicrobial evaluation; azo-Wittig reaction

Cite this article

Chen Yu , Bai Shun , Ai Yong , Fan Hua , Yang Guangzhong . Synthesis and Antimicrobial Evaluation of Novel Pyrimidoquinolines[J]. Chinese Journal of Organic Chemistry, 2013 , 33(05) : 1074 -1079 . DOI: 10.6023/cjoc201210020

References

[1] Ding, M-W. Sci. China, Ser B: Chem. 2010, 40, 869 (in Chinese).
(丁明武, 中国科学: 化学, 2010, 40, 869.)
[2] El-Gazzar, A. B. A.; Hafez, H. N.; Nawwar, G. A. M. Eur. J. Med. Chem. 2009, 44, 1427.
[3] Shrestha, A. R.; Ali, H. I.; Ashida, N.; Nagamatsu, T. Bioorg. Med. Chem. 2008, 16, 9161.
[4] Ali, H. I.; Tomita, K.; Akaho, E.; Kambara, H.; Miura, S.; Hayakawa, H.; Ashida, N.; Kawashima, Y.; Yamagishi, T.; Ikeya, H.; Yoneda, F.; Nagamatsu, T. Bioorg. Med. Chem. 2007, 15, 242.
[5] Metwally, K.; Aly, O.; Aly, E.; Banerjee, A.; Racindra, R.; Bane, S. Bioorg. Med. Chem. 2007, 15, 2434.
[6] Metwally, K.; Pratsinis, H.; Kletsas, D. Eur. J. Med. Chem. 2007, 42, 344.
[7] Ismaili, L.; Nadaradjane, A.; Nicod, L.; Guyon, C.; Xicluna, A.; Robert, J. F.; Refouvelet, B. Eur. J. Med. Chem. 2008, 43, 1270.
[8] Ding, M-W.; Liu, Z-J. Chin. J. Org. Chem. 2001, 21, 1 (in Chinese).
(丁明武, 刘钊杰, 有机化学, 2001, 21, 1.)
[9] Veronese, A. C.; Callegari, R.; Morelli, C. F. Tetrahedron 1995, 51, 12277.
[10] Zgoda, J. R.; Porter, J. R. Pharm. Biol. 2001, 39, 211.
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