SIOC 中文
CJOG
Adv search

Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 05: 1080 - 1087

DOI: https://doi.org/10.6023/cjoc201212020

Articles

Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties

  • Ma Xiaoye ,
  • Shi Lijun ,
  • Zhou Juan ,
  • Zhu Jun ,
  • Zhong Jian ,
  • Wei Ruili
Expand
  • a Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003;
    b National Engineering Research Center for Nanotechnology, Shanghai 200241;
    c College of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240

Received date: 2012-12-13

  Revised date: 2012-12-20

  Online published: 2013-01-04

Supported by

Project supported by the Army Medical Technology “12th Five-Year Plan” Scientific Research Projects of China (Surface Project, CWS11J131) and the Natural Science Foundation of Shanghai (11ZR1425200).

Fold

Abstract

A self-inflating hydrogel based on silk fibroin (SF) and poly(sodium acrylate) (PAAS) was synthesized by the free radical copolymerization. Furthermore, its potential as a tissue implant with minimally invasive treatment was investigated. The effects of the weight ratio of SF to AA (acrylic acid) on the structure, swelling properties and mechanical properties of the PAAS-SF semi-IPN hydrogels were investigated. In addition, the loading and release of amoxicillin of the PAAS-SF semi-IPN hydrogels were studied. With increasing SF content in the hydrogels, the swelling ratio and the rate of drug release increased, while the compressive strength decreased. It was observed that (83.4±0.9)% of the loaded drug was released within 120 h for the PAAS-SF20 semi-IPN hydrogels. The results revealed that the self-inflating PAAS-SF semi-IPN hydrogels with high swelling ratio and good drug releasing capabilities may have potential in the drug delivery or other implantable materials.

Key words： self-inflating; silk fibroin; poly(sodium acrylate); swelling ratio; drug release

Cite this article

Ma Xiaoye , Shi Lijun , Zhou Juan , Zhu Jun , Zhong Jian , Wei Ruili . Preparation of the Self-inflating Hydrogels Based on Poly(sodium acrylate) and Silk Fibroin and Their Drug Releasing Properties[J]. Chinese Journal of Organic Chemistry, 2013 , 33(05) : 1080 -1087 . DOI: 10.6023/cjoc201212020

References

[1] Kopecek, J. Biomaterials 2007, 28, 5185.
[2] Kim, J.; Peng, C.-C.; Chauhan, A. J. Controlled Release 2010, 148, 110.
[3] Sun, J.; Wang, Y.; Dou, S. Chin. Chem. Lett. 2012, 23, 97.
[4] Vashist, A.; Gupta, Y. K.; Ahmad, S. Carbohydr. Polym. 2011, 87, 1433.
[5] Schittkowski, M. P.; Guthoff, R. F. Br. J. Ophthalmol. 2006, 90, 1173.
[6] Kustner, M.; Riebeling, P.; Podmelle, F.; Kaduk, W.; Tost, F. Ophthalmologe 2009, 106, 1126.
[7] Swan, M. C.; Bucknall, D. G.; Goodacre, T. E. E.; Czernuszka, J. T. Acta Biomater. 2011, 7, 1126.
[8] Pescosolido, L.; Vermonden, T.; Malda, J.; Censi, R.; Dhert, W. J. A.; Alhaique, F.; Hennink, W. E.; Matricardi, P. Acta Biomater. 2011, 7, 1627.
[9] Wen, X.; Cao, X. L.; Yin, Z. H.; Wang, T.; Zhao, C. S. Carbohydr. Polym. 2009, 78, 193.
[10] Patel, R. B.; Solorio, L.; Wu, H.; Krupka, T.; Exner, A. A. J. Controlled Release 2010, 147, 350.
[11] Myung, D.; Koh, W.; Ko, J.; Hu, Y.; Carrasco, M.; Noolandi, J.; Ta, C. N.; Frank, C. W. Polymer 2007, 48, 5376.
[12] Yin, L.; Ding, J.; Fei, L.; He, M.; Cui, F.; Tang, C.; Yin, C. Int. J. Pharm. 2008, 350, 220.
[13] Mandal, B. B.; Kapoor, S.; Kundu, S. C. Biomaterials 2009, 30, 2826.
[14] Changez, M.; Burugapalli, K.; Koul, V.; Choudhary, V. Biomaterials 2003, 24, 527.
[15] Changez, M.; Koul, V.; Dinda, A. K. Biomaterials 2005, 26, 2095.
[16] Changez, M.; Koul, V.; Krishna, B.; Dinda, A. K.; Choudhary, V. Biomaterials 2004, 25, 139.
[17] Chang, C.; Duan, B.; Cai, J.; Zhang, L. Eur. Polym. J. 2010, 46, 92.
[18] de la Torre, P. M.; Torrado, S.; Torrado, S. Biomaterials 2003, 24, 1459.
[19] Rasool, N.; Yasin, T.; Heng, J. Y. Y.; Akhter, Z. Polymer 2010, 51, 1687.
[20] Vepari, C.; Kaplan, D. L. Prog. Polym. Sci. 2007, 32, 991.
[21] Li, C. M.; Vepari, C.; Jin, H. J.; Kim, H. J.; Kaplan, D. L. Biomaterials 2006, 27, 3115.
[22] Wenk, E.; Merkle, H. P.; Meinel, L. J. Controlled Release 2011, 150, 128.
[23] Kim, S. H.; Nam, Y. S.; Lee, T. S.; Park, W. H. Polym. J. 2003, 35, 185.
[24] Kundu, J.; Poole-Warren, L. A.; Martens, P.; Kundu, S. C. Acta Biomater. 2012, 8, 1720.
[25] Kweon, H.; Yeo, J.-H.; Lee, K.-G.; Lee, H. C.; Na, H. S.; Won, Y. H.; Cho, C. S. Biomed. Mater. 2008, 3, 034115.
[26] Hu, X.; Kaplan, D.; Cebe, P. Macromolecules 2008, 41, 3939.
[27] Teramoto, H.; Miyazawa, M. Biomacromolecules 2005, 6, 2049.
[28] Zhou, W.; Zhang, Y.; Jin, K.; Qiu, X.; Ren, X.; Hu, S.; Zhang, F. J. Appl. Polym. Sci. 2009, 114, 2828.
[29] Lu, Y.; Wang, D.; Li, T.; Zhao, X.; Cao, Y.; Yang, H.; Duan, Y. Y. Biomaterials 2009, 30, 4143.
[30] Ma, X.; Wei, R.; Cheng, J.; Cai, J.; Zhou, J. Carbohydr. Polym. 2011, 86, 313.
[31] Li, X.; Wu, W.; Wang, J.; Duan, Y. Carbohydr. Polym. 2006, 66, 473.
[32] Xu, Q.; Czernuszka, J. T. J. Controlled Release 2008, 127, 146.
[33] Torre, P. M.; Enobakhare, Y.; Torrado, G.; Torrado, S. Biomaterials 2003, 24, 1499.
[34] Lee, K. Y.; Mooney, D. J. Chem. Rev. 2001, 101, 1869.
[35] Zhou, J.; Cao, C.; Ma, X. Int. J. Biol. Macromol. 2009, 45, 504.
Options
Outlines

/

〈 〉