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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 05: 1108 - 1112

DOI: https://doi.org/10.6023/cjoc201210019

Notes

Synthesis and Biological Activity of N-[4-(Coumarin-3-yl)thiazol-2-yl] Aromatic Aldehyde Hydrazones under Microwave Irradiation

  • Yuan Mingyue ,
  • Liu Weihua ,
  • Zhang Yingqun ,
  • Yan Hongfei ,
  • Zhang Dongnuan ,
  • Liu Huimin ,
  • Wang Jianping
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  • a College of Science, Agricultural University of Hebei, Baoding 071001;
    b College of Plant Protection, Agricultural University of Hebei, Baoding 071001;
    c College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001

Received date: 2012-10-17

  Revised date: 2012-12-21

  Online published: 2013-01-07

Supported by

Project supported by the Foundation of Hebei Educational Committee (No. 2009435), the Non-life disciplines and Emerging Disciplines Foundation of Hebei Agricultural University (No. 2009020).

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Abstract

A series of N-[4-(coumarin-3-yl)thiazol-2-yl] aromatic aldehyde hydrazones have been prepared via the condensation of thiosemicarbazone with α-bromoacetyl coumarin, using microwave heating methodology. The yield was ranged from 69% to 97%. Their chemical structures have been confirmed by means of IR, 1H NMR and HRMS. Bioassay of the title compounds indicated that some of them exhibited good antibacterial activity.

Key words： N-[(4-(coumarin-3-yl)thiazol-2-yl) aromatic aldehyde hydrazones; synthesis; microwave; antibacterial activity

Cite this article

Yuan Mingyue , Liu Weihua , Zhang Yingqun , Yan Hongfei , Zhang Dongnuan , Liu Huimin , Wang Jianping . Synthesis and Biological Activity of N-[4-(Coumarin-3-yl)thiazol-2-yl] Aromatic Aldehyde Hydrazones under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, 2013 , 33(05) : 1108 -1112 . DOI: 10.6023/cjoc201210019

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