Articles

Synthesis and Bioactivity of Cyclic Polysulfides

  • Chen Jing ,
  • Yao Ligong ,
  • Guo Yuewei ,
  • Gong Jingxu
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  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received date: 2012-11-28

  Revised date: 2012-12-28

  Online published: 2013-01-07

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 81072572, 81273430, 21021063, 40976048, 31070310), the National Marine “863” Project (Nos. 2011AA09070102, 2013AA092902), the State Key Laboratory of Drug Research/Shanghai Institute of Materia Medica Projects (Nos. SIMM1203ZZ-03, SIMM1105KF-04 and SIMM1203KF-12) and partially funded by the EU 7th Framework Programme-IRSES Project (No. 246987).

Abstract

Fourteen cyclic polythiaethers, twelve of them are new compounds, were synthesized by condensation of dithiol with dichlorided compounds and then acylation. Their structures were characterized by 1H NMR, 13C NMR, HREIMS techniques. Some of the compounds were detected by X-ray. The PTP1B inhibitory activities of these compounds were tested.

Cite this article

Chen Jing , Yao Ligong , Guo Yuewei , Gong Jingxu . Synthesis and Bioactivity of Cyclic Polysulfides[J]. Chinese Journal of Organic Chemistry, 2013 , 33(05) : 1069 -1073 . DOI: 10.6023/cjoc201211048

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