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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 07: 1407 - 1422

DOI: https://doi.org/10.6023/cjoc201212033

Reviews

Recent Progress in the Research of Transition-Metal-Catalyzed C—CN Bond Cleavage

  • Kou Xuezhen ,
  • Fan Jiajun ,
  • Tong Xiaofeng ,
  • Shen Zengming
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  • a Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237;
    b School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240;
    c School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240

Received date: 2012-12-21

  Revised date: 2013-02-01

  Online published: 2013-02-05

Supported by

Project supported by the National Natural Sciences Foundation of China (Nos. 20272001, 20902058) and the Shanghai Education Committee (No. 13ZZ014).

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Abstract

Nitriles are an important class of organic compounds which can be found in pharmaceuticals, agrochemicals, dyes, and bioactive compounds. Transition-metal-catalyzed C—CN bond cleavage using inexpensive, simple and less toxic nitriles is one of the most attractive modern methods for the synthesis of complicated organic cyanides. Research progress of transition-metal-catalyzed (Ni, Pd, Rh, Cu, Ru, Fe, Mo, Co) different types of C—CN bond cleavage is reviewed, which includes some organic cyanides containing C(sp1)—CN bond, C(sp2)—CN bond and C(sp3)—CN bond. The C—CN cleavage mechanisms are also discussed in this review.

Key words： transition metal; C—CN bond cleavage; mechanism

Cite this article

Kou Xuezhen , Fan Jiajun , Tong Xiaofeng , Shen Zengming . Recent Progress in the Research of Transition-Metal-Catalyzed C—CN Bond Cleavage[J]. Chinese Journal of Organic Chemistry, 2013 , 33(07) : 1407 -1422 . DOI: 10.6023/cjoc201212033

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