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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 07: 1587 - 1590

DOI: https://doi.org/10.6023/cjoc201212051

Notes

Concise Synthesis of Lucidone and Methyl Lucidone

  • Liu Wu ,
  • Xiao Fenfen ,
  • Hu Xiangdong
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  • Department of Chemistry & Material Science, Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education of China, Northwest University, Xi'an 710069

Received date: 2012-12-31

  Revised date: 2013-01-28

  Online published: 2013-02-05

Supported by

Project supported by the National Natural Science Foundation of China (No. 21002078).

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Abstract

The concise synthesis of lucidone and methyl lucidone is reported. The key steps include the "one-pot" reduction/rearrangement of dimethyl squarate and the Darzens/ring expansion of the monomethoxyl cyclobutenedione. The synthesis of lucidone was finished in two steps and 46% total yield. And the synthesis of methyl lucidone had been reached in three steps and 43% overall yield.

Key words： lucidone; methyl lucidone; cyclobutenedione; Darsens/ring expansion; concise synthesis

Cite this article

Liu Wu , Xiao Fenfen , Hu Xiangdong . Concise Synthesis of Lucidone and Methyl Lucidone[J]. Chinese Journal of Organic Chemistry, 2013 , 33(07) : 1587 -1590 . DOI: 10.6023/cjoc201212051

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