SIOC 中文
CJOG
Adv search

Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 07: 1503 - 1508

DOI: https://doi.org/10.6023/cjoc201210044

Articles

Synthesis and Antifungal Activity of 2-Carbalkoxyalkyl/(n-butyl)-4-aryl-1,5-benzothiazepines

  • Li Wenhong ,
  • Liu Xiying ,
  • Zhang Bo ,
  • Li Yuan
Expand
  • a College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050024;
    b Environment and Chemical Engineering, Hebei College of Industry and Technology, Shijiazhuang 050091

Received date: 2013-10-23

  Revised date: 2013-01-18

  Online published: 2013-02-22

Supported by

Project supported by the National Natural Science Foundation of China (No. 20972040), the Research Project of Education Department of Hebei Province of China (No. Q2012001), and the Scientific Research Fund of Hebei College of Industry and Technology (No. Qz1102).

Fold

Abstract

A series of novel 2-substituted-1,5-benzothiazepines were synthesized successfully and their structures were determined by elemental analysis, IR, MS/HRMS and 1H NMR. The synthetic conditions of 2-substituted-4-aryl-1,5-benzothiazepines were investigated. The antifungal activities of these 2-substituted-1,5-benzothiazepine derivatives were tested and the results confirmed that the 2-ethyl carboxylate was necessary for antifungal activity in 1,5-benzothiazepine compounds 1.

Key words： 1,5-benzothiazepine; synthesis; antifungal activities; structure-activity relationship

Cite this article

Li Wenhong , Liu Xiying , Zhang Bo , Li Yuan . Synthesis and Antifungal Activity of 2-Carbalkoxyalkyl/(n-butyl)-4-aryl-1,5-benzothiazepines[J]. Chinese Journal of Organic Chemistry, 2013 , 33(07) : 1503 -1508 . DOI: 10.6023/cjoc201210044

References

[1] Nagao, T.; Sato, M.; Nakajima, H.; Kiyomoto, A. Chem. Pharm. Bull. 1973, 21(1), 92.
[2] Maruenda, H.; Johnson, F. J. Med. Chem. 1995, 38, 2145.
[3] Disanto, R.; Costi, R. Farmaco 2005, 60, 385.
[4] Garg, N.; Chandra, T.; Archana, J. A. B.; Kumar, A. Eur. J. Med. Chem. 2010, 45, 1529.
[5] Ichikawa, M.; Yokomizo, A.; Itoh, M.; Sugita, K.; Usui, H.; Shimizu, H.; Suzuki, M.; Terayama, K.; Kanda, A. Bioorg. Med. Chem. 2011, 19, 1930.
[6] Karale, S. N.; Pratap, U. R.; Mahalle, S. R.; Mane, R. A. J. Sulfur Chem. 2011, 32(4), 303.
[7] Dandia, A.; Singh, R.; Singh, D.; Laxkar, A.; Sivpuri, A. Phosphorus, Sulfur, Silicon Relat. Elem. 2010, 185, 2472.
[8] Chate, A. V.; Joshi, R. S.; Badadhe, P. V.; Dabhade, S. K.; Gill, C. H. Bull. Korean Chem. Soc. 2011, 32(11), 3887.
[9] Ghotekar, D. S; Joshi, R. S.; Mandhane, P. G.; Bhagat, S. S.; Gill, C. H. Indian J. Chem. 2010, 49B(9), 1267.
[10] Zhang, P.; Xuan, Y.; Liu, W.; Li, Y. Chin. J. Org. Chem. 2011, 31, 1240 (in Chinese). (张萍, 宣烨, 刘薇, 李媛, 有机化学, 2011, 31, 1240.)
[11] Li, W.-H.; Zhang, L.-F.; Liu, W.; Du, X.-Q.; Li, Y. Chin. J. Org. Chem. 2011, 31, 1252 (in Chinese). (李文红, 张玲芬, 刘薇, 杜星琼, 李媛, 有机化学, 2011, 31, 1252.)
[12] Wu, H.-S. M.S. Thesis, Hebei Normal University, Shijianzhuang, 2008 (in Chinese). (吴惠姝, 硕士论文, 河北师范大学, 石家庄, 2008.)
[13] Anand, R. C.; Selvapalam, N. Synth. Commun. 1994, 24, 2743.
[14] Gannett, P. M.; Nagel, D. L.; Reilly, P. J.; Lawson, T.; Sharpe, J.; Toth, B. J. Org. Chem. 1988, 53(5), 1064.
[15] Yang, S.-X.; Yang, X.-L.; Lu, Y.-Y.; Sun, Y.-F.; Sun, L.; Ling, Y. Chin. J. Org. Chem. 2010, 30, 1543 (in Chinese). (杨绍祥, 杨新玲, 卢园园, 孙玉凤, 孙亮, 凌云, 有机化学, 2010, 30, 1543.)
Options
Outlines

/

〈 〉