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DOI: https://doi.org/10.6023/cjoc201301009

Notes

Synthesis and Characterization of Dihydrazide Derivatives Containing Benzimidazole Ring

  • Li Yingjun ,
  • Yu Yang ,
  • Xu Yongting ,
  • Jin Kun ,
  • Luo Tongchuan ,
  • Shao Xin ,
  • Shi Xiangling ,
  • Wu Jianghong
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  • a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029;
    b Analysis and Inspection Center, Liaoning Normal University, Dalian 116029;
    c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012

Online published: 2013-03-07

Supported by

Project supported by the Natural Science Foundation of Liaoning Province (No. 20102126).

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Abstract

Ten novel dihydrazide derivatives containing benzimidazole ring (7a～7j) were synthesized by (un)substituted phenol and chloroacetic acid as starting materials via a series of reactions. The structure of representative compound 7c was confirmed by its 1H NMR, 13C NMR, 2D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and variable-temperature 1H NMR spectra. The experimental results indicate that compound 7c in DMSO at room temperature exists in the tautomeric A and B isomers, and A isomer is dominant (87.65%). On the basis of the analytic results of compound 7c, 1H NMR spectra of other target compounds were also assigned and the content of dominant A isomer is in the range of 80.55%~89.90%.

Key words： dihydrazide; synthesis; characterization

Cite this article

Li Yingjun , Yu Yang , Xu Yongting , Jin Kun , Luo Tongchuan , Shao Xin , Shi Xiangling , Wu Jianghong . Synthesis and Characterization of Dihydrazide Derivatives Containing Benzimidazole Ring[J]. Chinese Journal of Organic Chemistry, 0 , (0) : 0 -0 . DOI: 10.6023/cjoc201301009

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