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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1319 - 1325

DOI: https://doi.org/10.6023/cjoc201301006

Articles

Synthesis of 3-[(Z)-Pentadec-8-enyl]catechol and Its Anti-angiogenesis Activity

  • Yang Mei ,
  • He Jiangbo ,
  • Cheng Yongxian ,
  • Jiang Sheng
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  • a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204;
    b Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530;
    c University of Chinese Academy of Sciences, Beijing 100039

Received date: 2013-01-04

  Revised date: 2013-03-07

  Online published: 2013-03-15

Supported by

Project supported by the National Natural Science Foundation of China (No.U1202222), and the State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (No.P2010-ZZ09).

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Abstract

3-[(Z)-Pentadec-8-enyl]catechol (GQ-5) was produced from 2,3-dimethoxybenzaldehyde through Barbier coupling reaction, the conversion of protecting group from methyl ether to acetonylidene, Wittig reaction and so on.These compounds have been confirmed by 1H NMR, 13C NMR and MS (or HRMS) techniques.Meanwhile, anti-angiogenesis activity of compound GQ-5 was evaluated by using HUVEC cells.

Key words： urushiol; resina toxicodendri; Wittig reaction; angiogenesis

Cite this article

Yang Mei , He Jiangbo , Cheng Yongxian , Jiang Sheng . Synthesis of 3-[(Z)-Pentadec-8-enyl]catechol and Its Anti-angiogenesis Activity[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1319 -1325 . DOI: 10.6023/cjoc201301006

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