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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 07: 1536 - 1539

DOI: https://doi.org/10.6023/cjoc201301039

Notes

Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles

  • Zheng Juan ,
  • Chen Yu ,
  • Wu Kongli ,
  • Ran Chunling ,
  • Xu Yan ,
  • Song Maoping
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  • a College of Chemistry and Molecular Engineering, Zhengzhou 450001;
    b College of Basic Medicine, Zhengzhou University, Zhengzhou 450001

Received date: 2013-01-16

  Revised date: 2013-03-07

  Online published: 2013-03-15

Supported by

Project supported by the National Natural Science Foundation of China (No. 21171149).

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Abstract

Four new 2,5-disubstituted 1,3,4-oxadiazole derivative N-(5-aromatic-1,3,4-oxadiazol-2-yl)picolinamides 2a～2d were obtained by condensation, oxidization and acylation reactions, with isonicotinic acid and single substituted aromatic aldehydes as raw materials. These compounds were characterized by IR, 1H NMR and elemental analysis. Fluorescence test results indicated that Cu2+ could make this series compounds fluorescence quenching, and Zn2+could only enhance the fluorescence intensity of N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]isonicotinamide (2b). Furthermore, those compounds all showed good fungicidal activity against the tested bacteria, and among them, N-(5-p-tolyl-1,3,4-oxadiazol-2-yl)isonicotinamide (2d) against Gibberella zeae was reached 100%.

Key words： 1,3,4-oxadiazole; fluorescence; biological activity

Cite this article

Zheng Juan , Chen Yu , Wu Kongli , Ran Chunling , Xu Yan , Song Maoping . Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles[J]. Chinese Journal of Organic Chemistry, 2013 , 33(07) : 1536 -1539 . DOI: 10.6023/cjoc201301039

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