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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 08: 1769 - 1773

DOI: https://doi.org/10.6023/cjoc201301066

Articles

Synthesis of Poly-L-lysine and Its Structural Response to Environmental pH

  • Wu Shengrong ,
  • Geng Xin ,
  • Chen Cai ,
  • Cai Yikang ,
  • Han Guozhi
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  • College of Science, Nanjing University of Technology, Nanjing 210009

Received date: 2013-01-25

  Revised date: 2013-03-15

  Online published: 2013-04-09

Supported by

Project supported by the Postdoctoral Foundation of China (No. 20100481084).

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Abstract

Using L-lysine as raw material, Polylysine (PLL) was synthesized through four steps. The structures of intermediums and the final product were confirmed by IR and 1H NMR. Furthermore, some key synthetic steps were optimized in the process. On the basis, response ability to environmental pH of PLL structures was investigated by SEM and circular dichroism spectra. Experimental results indicated that polypeptide structure of PLL has good response ability to pH of environment. Under different pH conditions, distinct morphology was formed. Under acidic conditions, PLL presented a specific coil conformation, whereas orderly pine needle was observed under alkaline conditions.

Key words： polylysine; N-carboxy-(Nε-benzyloxycarbonyl)-L-lysine anhydride (NCA); synthesis; pH; response

Cite this article

Wu Shengrong , Geng Xin , Chen Cai , Cai Yikang , Han Guozhi . Synthesis of Poly-L-lysine and Its Structural Response to Environmental pH[J]. Chinese Journal of Organic Chemistry, 2013 , 33(08) : 1769 -1773 . DOI: 10.6023/cjoc201301066

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