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Chemical Constituent and Biological Activities of the Genus Iris

  • Yang Yang ,
  • Chen Jiejun ,
  • Zhang Dayong ,
  • Dong Xiaofang ,
  • Zhao Changqi
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  • a Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Key Laboratory of Gene Engineering Drugs & Biological Technology, College of Life Science, Beijing Normal University, Beijing 100875;
    b Biosource and Biosafety Division China National Center for Biotechnology Development, Ministry of Science and Technology, Beijing 100039

Received date: 2013-02-17

  Revised date: 2013-03-29

  Online published: 2013-04-09

Supported by

Project supported by the Twelfth Five-Year Plan "Essential Drug Research and Development" Major Projects of Science and Technology (No.2013ZX09103001-019-001) and the National Basic Research Program of China (973 program, No.2007CB10680002)

Abstract

Species of the genus Iris (Iridaceae) have a long history of traditional medicinal use in many places of the world, and are used in the treatment of cancer, inflammation, bacterial and viral infections. Iris plants have been previously recognized as rich sources of secondary metabolites, which mainly belong to flavonoids, triterpenoids, benzoquinones and stilbenes.As the predominant component, flavonoids have been frequently reported.This paper describes 65 triterpenoids including iridals which is a kind of unusual triterpenoids isolated from various Iris species, 21 benzoquinones and 9 stilbenes from 21 Iris species since 1982, and the details of their source, structure are given.And the possible biogenetic ways of iridals are also presented.Moreover, many of these compounds exhibited anticancer, antimalarial, ecdysteroid antagonist, antioxidant, enzyme inhibitor, antiulcer properties.

Cite this article

Yang Yang , Chen Jiejun , Zhang Dayong , Dong Xiaofang , Zhao Changqi . Chemical Constituent and Biological Activities of the Genus Iris[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1244 -1253 . DOI: 10.6023/cjoc201302013

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