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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1284 - 1290

DOI: https://doi.org/10.6023/cjoc201303041

Articles

Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

  • Zhao Mian ,
  • Cai Le ,
  • He Jianmin ,
  • Yin Tianpeng ,
  • Sui Yingchun ,
  • Luo Mengting ,
  • Ding Zhongtao
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  • a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091;
    b College of Resource and Environment, Baoshan University, Baoshan 678000

Received date: 2013-03-26

  Revised date: 2013-04-25

  Online published: 2013-05-06

Supported by

Project supported by the National Natural Science Foundation of China (No.21002084), and the Natural Science Foundation of China of Yunnan Province (No.2010CD017).

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Abstract

Seventeen compounds were isolated from the branches and leaves of Pyrus pashia Buch.-Ham.ex D.Don.On the basis of spectroscopic methods (HR-ESIMS, 1D- and 2D-NMR), their structures were identified as pashinin A (1), gastrodin-7-O-cis-caffeoyl ester (2), gastrodin-7-O-trans-caffeoyl ester (3), kaempferol-3-β-D-(6-O-trans-p-coumaroyl)glu- copyranoside (4), kaempferol-3-β-D-(6-O-cis-p-coumaroyl)glucopyranoside (5), gastrodin-7-O-p-hydroxybenzoyl ester (6), arbutin (7), robustaside B (8), tormentic acid (9), euscaphic acid (10), quercetin-3-O-β-D-glucopyranoside (11), 2R,3R-dihydyoquercetin (12), luteolin-4'-O-β-D-glucopyranoside (13), apigenin-4'-O-β-D-glucopyranoside (14), 5,7,4'-trihy- droxyisoflavone-7-O-β-D-glucopyranoside (15), genistein (16), caffeic acid (17).Among them, 1 and 2 were new compounds, 3 was a new natural product, 4～16 were isolated from this plant for the first time.Compounds 1～3 showed no cytotoxic effects on tumor cell (IC50 >40 μmol·L-1).1 and 4 exhibited weak anti-HIV-1 activities.

Key words： Pyrus pashia; branches and leaves; pashinin A; gastrodin-7-O-cis-caffeoyl ester; anti-HIV-1 activities

Cite this article

Zhao Mian , Cai Le , He Jianmin , Yin Tianpeng , Sui Yingchun , Luo Mengting , Ding Zhongtao . Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1284 -1290 . DOI: 10.6023/cjoc201303041

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