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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 10: 2098 - 2107

DOI: https://doi.org/10.6023/cjoc201303020

Reviews

Recent Developments in the Synthesis of Fluorine-Containing β-Amino Acids and β-Lactams

  • Lin Daizong ,
  • Wang Jiang ,
  • Liu Hong
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  • State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203

Received date: 2013-03-15

  Revised date: 2013-04-23

  Online published: 2013-05-09

Supported by

Project supported by the National Natural Science Foundation of China (No. 81025017).

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Abstract

Fluorine-containing β-amino acids and β-lactams have attracted appreciable attention due to their wide application in organic chemistry, drug discovery, and protein biology. Accordingly, the development of efficient synthetic methods is of considerable interest in academia and industry. The synthesis and resolution are achieved. This review briefly summarizes the recent development in the methodologies for the synthesis of fluorine-containing β-amino acids and β-lactams with classification by the species of the fluorine-containing β-amino acids (α-fluorinated β-amino acids, α-trifluoromethyl β-amino acids, and β-trifluoromethyl β-amino acids).

Key words： fluorine-containing β-amino acid; fluorine-containing β-lactam; synthesis

Cite this article

Lin Daizong , Wang Jiang , Liu Hong . Recent Developments in the Synthesis of Fluorine-Containing β-Amino Acids and β-Lactams[J]. Chinese Journal of Organic Chemistry, 2013 , 33(10) : 2098 -2107 . DOI: 10.6023/cjoc201303020

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