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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1235 - 1243

DOI: https://doi.org/10.6023/cjoc201303044

Reviews

Recent Progress in the Synthesis of Tamiflu

  • Zhang Tiancai ,
  • Lu Hui ,
  • Zhang Fu-Min ,
  • Cheng Jun ,
  • Liu Tianyang
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  • State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000

Received date: 2013-03-27

  Revised date: 2013-05-09

  Online published: 2013-05-13

Supported by

Project supported by the National Natural Science Foundation of China (Nos.20972059, 21290180), the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1138) and the Fundamental Research Funds for the Central Universities (No.lzujbky-2013-ct02).

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Abstract

Tamiflu, one of the most common orally drugs for the treatment and prevention of influenza, has attracted extensive interests of synthetic chemists all over the world.Concise, efficient, and scalable synthetic approaches toward this molecule have been a very active field in recent years, and many diverse synthetic routes have been developed to date.In this review, representative synthetic routes employing chiral starting material or catalytic asymmetric reactions are briefly summarized.

Key words： tamiflu; drug; total synthesis

Cite this article

Zhang Tiancai , Lu Hui , Zhang Fu-Min , Cheng Jun , Liu Tianyang . Recent Progress in the Synthesis of Tamiflu[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1235 -1243 . DOI: 10.6023/cjoc201303044

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