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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 9: 1970 - 1974

DOI: https://doi.org/10.6023/cjoc201304014

Articles

Synthesis and Cytotoxicity of E-Hesperetin Oximes against SGC-7901

  • Liu Zhiping ,
  • Wei Wanxing ,
  • Gan Chunfang ,
  • Huang Yanmin ,
  • Liu Sheng ,
  • Cui Jianguo
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  • a Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001;
    b College of Chemistry and Chemical Engineer, Guangxi University, Nanning 530004

Received date: 2013-04-12

  Revised date: 2013-05-04

  Online published: 2013-05-13

Supported by

Project supported by the National Natural Science Foundation of China (No. 81060261) and the Natural Science Foundation of Guangxi Province (Nos. 2011GXNSFD018016, 2012GXNSFAA053021)

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Abstract

Used natural hesperetin (1) as raw material, persicogenin (2) and 7-O-isopentenyl hesperetin (3) were obtained by the mothod of selective methylation and selective O-prenylation. Nine E-hesperetin oximes 4～12 were synthesiszed by reaction of 1～3 with hydroxylamine hydrochloride, methoxylamine hydrochloride and benzyloxygen amine hydrochloride, respectively. Their structures were confirmed by NMR and HR-ESI-MS. The synthesized compounds were evaluated for cytotoxicity against human cancer cell line SGC-7901. The result showed that compounds 4～6 exhibited dictinct cytotoxicity against SGC-7901.

Key words： hesperetin; hesperetin oximes; synthesis; cytotoxicity

Cite this article

Liu Zhiping , Wei Wanxing , Gan Chunfang , Huang Yanmin , Liu Sheng , Cui Jianguo . Synthesis and Cytotoxicity of E-Hesperetin Oximes against SGC-7901[J]. Chinese Journal of Organic Chemistry, 2013 , 33(9) : 1970 -1974 . DOI: 10.6023/cjoc201304014

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