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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1144 - 1156

DOI: https://doi.org/10.6023/cjoc201304035

Reviews

Progress in Synthesis of 3,4-Fused Indole Alkaloids

  • Shan Dong ,
  • Jia Yanxing
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  • State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191

Received date: 2013-04-22

  Revised date: 2013-05-13

  Online published: 2013-05-15

Supported by

Project supported by the National Natural Science Foundation of China (Nos.21290180, 20972007), the National Basic Research Program of China (973 Program) (No.2010CB833200) and the Ph.D.Programs Foundation of Ministry of Education of China (No.20120001110100).

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Abstract

The indole nucleus is one of the most important heterocycles for its presence in a vast number of bioactive natural products, pharmaceuticals, and agrochemicals.Due to their widest spectrum of biological activity and some of them have been used in clinical trials, construction and functionalization of indoles have attracted considerable interests from synthetic and medicinal chemists for over a hundred years.Among the naturally occurring indole alkaloids, those containing 3,4-fused indole skeleton possess a major part and have been especially considered attractive synthetic targets because of their unique structure and biological activities.This review emphasized on the methodologies and strategies of construction of 3,4-fused indole skeleton, and their application in total synthesis of natural products.

Key words： indole alkaloids; 3,4-fused indoles; natural products; total synthesis

Cite this article

Shan Dong , Jia Yanxing . Progress in Synthesis of 3,4-Fused Indole Alkaloids[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1144 -1156 . DOI: 10.6023/cjoc201304035

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