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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1186 - 1194

DOI: https://doi.org/10.6023/cjoc201303056

Reviews

Research Progress on the Synthesis of Stenine

  • Chen Jingbo ,
  • Chen Jingchao ,
  • Xie Yan ,
  • Liu Nana ,
  • Liu Dandan ,
  • Zhang Hongbin
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  • Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan University, Kunming 650091

Received date: 2013-03-31

  Revised date: 2013-05-21

  Online published: 2013-05-24

Supported by

Project supported by the the National Natural Science Foudation of China (Nos.21062029, 20562013, 20925205).

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Abstract

The alkaloid stenine which has a representative pyrrolo[1,2-a]azepine nucleus and a highly substituted perhydroindole ring system is unique among Stemona alkaloids.The polycyclic system and the seven contiguous stereogenic centers in (-)-stenine present a challenge for asymmetric organic synthesis.Progresses toward the synthesis of stenine are reviewed in terms of the key strategies employed.

Key words： stenine; racemic synthesis; asymmitric synthesis

Cite this article

Chen Jingbo , Chen Jingchao , Xie Yan , Liu Nana , Liu Dandan , Zhang Hongbin . Research Progress on the Synthesis of Stenine[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1186 -1194 . DOI: 10.6023/cjoc201303056

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