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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 9: 1988 - 1993

DOI: https://doi.org/10.6023/cjoc201304028

Notes

Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues

  • Liu Zhiping ,
  • Wei Wanxing ,
  • Gan Chunfang ,
  • Huang Yanmin ,
  • Liu Sheng ,
  • Zhou Min ,
  • Cui Jianguo
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  • a College of Chemistry and Chemical Engineer, Guangxi University, Nanning 530004;
    b College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001

Received date: 2013-04-18

  Revised date: 2013-05-22

  Online published: 2013-05-31

Supported by

Project supported by the National Natural Science Foundation of China (No. 81060261) and the Natural Science Foundation of Guangxi Province (No. 2011jjD20002)

Fold

Abstract

Hesperitin hydrazone (2) was generated by the reaction of natural hesperitin (1) as raw material with hydrazine hydrate. Eight N-benzylidene hesperitin hydrazones 3～10 and six analogues 11～16 were synthesized by the reaction of 2 with various aldehydes, respectively. The structures of all reaction products were confirmed by NMR, IR and HR-MS techniques. And the cytotoxity against human cancer cell SGC-7901 of the synthesized compounds was also evaluated. The results showed 5, 7, 10 and 16 exhibiting distinct cytotoxity against SGC-7901.

Key words： hesperitin; hesperitin hydrazones; N-benzylidene; cytotoxicity

Cite this article

Liu Zhiping , Wei Wanxing , Gan Chunfang , Huang Yanmin , Liu Sheng , Zhou Min , Cui Jianguo . Synthesis and Cytotoxicity of N-Benzylidene Hesperitin Hydrazones and Analogues[J]. Chinese Journal of Organic Chemistry, 2013 , 33(9) : 1988 -1993 . DOI: 10.6023/cjoc201304028

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