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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 06: 1333 - 1336

DOI: https://doi.org/10.6023/cjoc201305025

Notes

A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.

  • Li Xiaobao ,
  • Song Xiaoping ,
  • Chen Guangying ,
  • Han Changri ,
  • Chen Wenhao ,
  • Zheng Caijuan ,
  • Song Xinming
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  • Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received date: 2013-05-15

  Revised date: 2013-05-28

  Online published: 2013-06-04

Supported by

Project supported by the National Natural Science Foundation of China (Nos.81160391, 21166009 and 21162009), the 973 Research Program of the Ministry of Science and Technology of China (No.2011CB512010).

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Abstract

Eight clerodane-type compounds were isolated from the roots of Polyalthia laui and purified by silica gel column chromatorgraphy and preparative thin layer chromatorgraphy (TLC).Their structures were elucidated as polyalimide A (1),kolavenic acid (2), 2-oxo-kolavenic acid (3), 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (4), 3,4-dihydroxyclerodan-13E-en-15-oic acid (5), longimide B (6), 16-oxocleroda-3,13E-dien-15-oic acid (7), and solidagonal acid methyl ester (8).Compound 1 was a novel compound and compound 5 was isolated from this family for the first time, and all compounds were isolated for the first time from this plant material.Compounds 2 and 3 showed weakly inhibitory activities against SPC-A-1, SGC-7901 and K-562 human tumor cells.

Key words： Polyalthia; Polyalthia laui Merr.; polyalimide A

Cite this article

Li Xiaobao , Song Xiaoping , Chen Guangying , Han Changri , Chen Wenhao , Zheng Caijuan , Song Xinming . A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.[J]. Chinese Journal of Organic Chemistry, 2013 , 33(06) : 1333 -1336 . DOI: 10.6023/cjoc201305025

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