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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 10: 2237 - 2243

DOI: https://doi.org/10.6023/cjoc201305039

Notes

Studies on the Synthesis, Crystal Structure and Antimicrobial Activities of 4-Methyl-2-heterocylic-2,3-dihydro-benzo[f]-1,5-thiazepine-3-carboxylic Acid Ethyl Ester and Its Reduction Products

  • Tian Keqing ,
  • Liu Xiaoxin ,
  • Xue Ziqiao ,
  • Yang Tian ,
  • Du Xingqiong ,
  • Zhang Ping
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  • a Environment and Chemical Engineering, Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026;
    b College of Chemistry, Hebei Normal University, Shijiazhuang 050024;
    c College of Life Science, Hebei Normal University, Shijiazhuang 050024

Received date: 2013-05-24

  Revised date: 2013-06-10

  Online published: 2013-06-21

Supported by

Project supported by the National Natural Science Foundation of China (No. 20972040).

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Abstract

Starting from ethyl acetoacetate and substituted heterocyclic aldehyde, a series of new 4-methyl-2-heterocyclic-2,3-dihydro-benzo[f]-1,5-thiazepine-3-carboxylic acid ethyl esters (2a～2l) were synthesized through 2-step reactions, and of which five compounds were reduced. The structures of the compounds were characterized by 1H NMR, IR, MS, elemental analysis and X-ray diffraction study. The crystal of compound 2a belongs to triclinic system, space group P-1. The antibacterical activities of the new compounds against B. subtilis, C. albicans and C. neoformans were evaluated by filter paper approach, and the results indicated that most of them showed antibacterical activities, especially the compound 2a prominent.

Key words： 1,5-benzothiazepine; heterocyclic; reduction; crystal structure; antibacterical activity

Cite this article

Tian Keqing , Liu Xiaoxin , Xue Ziqiao , Yang Tian , Du Xingqiong , Zhang Ping . Studies on the Synthesis, Crystal Structure and Antimicrobial Activities of 4-Methyl-2-heterocylic-2,3-dihydro-benzo[f]-1,5-thiazepine-3-carboxylic Acid Ethyl Ester and Its Reduction Products[J]. Chinese Journal of Organic Chemistry, 2013 , 33(10) : 2237 -2243 . DOI: 10.6023/cjoc201305039

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