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Chinese Journal of Organic Chemistry >

2013 , Vol. 33 >Issue 10: 2155 - 2161

DOI: https://doi.org/10.6023/cjoc201305045

Articles

Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids

  • Yang Jinhui ,
  • Xie Yimin ,
  • Feng Shangbiao ,
  • Zuo Wubiao ,
  • Chen Bingbing ,
  • Ma Xiaoqin ,
  • Feng Yao
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  • State Key Laboratory Cultivation Base of Natural Gas Conversion, Ningxia University, Yinchuan 750021

Received date: 2013-05-27

  Revised date: 2013-06-13

  Online published: 2013-06-25

Supported by

Project supported by the National Natural Science Foundation of China (No. 21162021) and the Program for New Century Excellent Talents in University (No. NCET-09-0860).

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Abstract

Abyssinone-Ⅴ, 4'-hydroxy-6,3',5'-triprenylisoflavonone, abyssinone-Ⅵ and abyssinone-Ⅳ were all isolated from the genus erythrina. This study completed the first total synthesis of four natural prenylated flavanoids by using simple and facile approaches. The result of their in vitro antibacterial tests indicated that all of them displayed moderate bacteriostatic activities. The compounds abyssinone-Ⅳ and abyssinone-Ⅴ showed remarkable antibacterial activities. The structures of all new compounds have been confirmed by HRMS, 1H NMR and 13C NMR spectra.

Key words： prenylated flavanoid; (±)-abyssinone-Ⅵ; (±)-abyssinone-Ⅳ; (±)-abyssinone-Ⅴ; 4'-hydroxy-6,3',5'-triprenyli-soflavonone; total synthesis; antibacterial activity

Cite this article

Yang Jinhui , Xie Yimin , Feng Shangbiao , Zuo Wubiao , Chen Bingbing , Ma Xiaoqin , Feng Yao . Total Synthesis and Antibacterial Activities of Four Natural Dual Prenylated Flavonoids[J]. Chinese Journal of Organic Chemistry, 2013 , 33(10) : 2155 -2161 . DOI: 10.6023/cjoc201305045

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