Chinese Journal of Organic Chemistry >
One-Pot Three Components Synthesis of β-Amido Ketones
Received date: 2013-06-06
Revised date: 2013-07-10
Online published: 2013-07-26
Supported by
Project supported by the Foundation of Beijing Institute of Technology.
A series of β-amido-ketones were synthesized by one-pot three components condensation of various aldehydes, ketones and nitriles in the presence of TiCl4 with the assistance of acyl chloride at room temperature. The effects of amount of catalyst, reaction temperature and reaction time on the products yields were investigated. This methodology offers several ad-vantages, such as mild reaction condition, operational simplicity, suitable for wide range of substrates, and excellent yields.
Yang Deli , Li Jiarong , Sun Kening , Lu Hongyan , Liu Mingxing , Shi Daxin . One-Pot Three Components Synthesis of β-Amido Ketones[J]. Chinese Journal of Organic Chemistry, 2013 , 33(11) : 2341 -2348 . DOI: 10.6023/cjoc201306007
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