Notes

Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives

  • Xie Feng ,
  • Liu Tingting ,
  • Yang Guo ,
  • Yuan Jing ,
  • Kong Xiaolin ,
  • Xu Tianming ,
  • Tan Chengxia
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  • a College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014;
    b Sinochem Lantian Zhejiang Research Institute of Chemical Industry Co. Ltd., Hangzhou 310023

Received date: 2013-07-04

  Revised date: 2013-08-01

  Online published: 2013-08-29

Supported by

Project supported by the National Key Technologies R&D Program (No. 2011BAE06B03-01) and the Key Innovation Team of Science and Technology in Zhejiang Province (No. 2010R50018).

Abstract

To find new lead compounds with high acaricidal bioactivity, ten new 1H-pyrazole-4-carboxamide derivatives were designed and synthesized by combining with the 1,3,5-trimethyl-1H-pyrazole-4-carboxamide moiety in pyflubumide and diaryl ether moiety in flufenoxuron. Their structures were confirmed by 1H NMR, MS and elemental analyses. The acaricidal activities of these compounds were evaluated by pesticide bioassay procedure. The results showed that most of title compounds exhibited significant effect against Tetranychus cinnabarinus with 90.0% death rate at 500 mg/L.

Cite this article

Xie Feng , Liu Tingting , Yang Guo , Yuan Jing , Kong Xiaolin , Xu Tianming , Tan Chengxia . Synthesis and Acaricidal Activity of New 1H-Pyrazole-4-carboxamide Derivatives[J]. Chinese Journal of Organic Chemistry, 2013 , 33(12) : 2596 -2601 . DOI: 10.6023/cjoc201307006

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