Chinese Journal of Organic Chemistry >
Two New Diterpenoid Alkaloids from the Roots of Aconitum duclouxii Levl
Received date: 2013-07-17
Revised date: 2013-08-13
Online published: 2013-08-29
Supported by
Project supported by the National Natural Science Foundation of China (No. 21002084), the Natural Science Foundation of Yunnan Province (No. 2010CD017), and an Undergraduates Innovative Experiment Project from Yunnan Province.
Two new C-19-diterpenoid alkaloids, ducloudines A (1) and B (2), together with two known alkaloids of 14-acetylneoline (3) and aconitine (4), were isolated from the roots of Aconitum duclouxii Levl. The structures of new alkaloids were established on the basis of spectral data (HR-MS, X-ray crystallographic analysis, 1D-and 2D-NMR). Cytotoxicities of compounds 1 and 2 were tested against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, SW480). Results showed that compounds 1 and 2 had no cytotoxic effects on these five tumor cells (IC50 > 40 μmol/L).
Key words： Aconitum duclouxii; diterpenoid alkaloids; ducloudine A; ducloudine B; cytotoxicity
Yin Tianpeng , Cai Le , Lei Gang , Dong Jianwei , Liu Yanxiong , Ding Zhongtao . Two New Diterpenoid Alkaloids from the Roots of Aconitum duclouxii Levl[J]. Chinese Journal of Organic Chemistry, 2013 , 33(12) : 2528 -2532 . DOI: 10.6023/cjoc201307025
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