Chinese Journal of Organic Chemistry >
Synthesis and Herbicidal Activity of Novel N-Hetrocyclo Containing Nitrogen Methoxy-O-(4-aryloxy-phenyl) Lactamide Derivatives
Received date: 2013-07-12
Revised date: 2013-09-12
Online published: 2013-09-30
Supported by
Project supported by the National Basic Research Program of China (973 Program, No. 2010CB126104), the National Research Foundation for the Doctoral Program of Higher Education of China (No. 20040532002), the Natural Science Foundation of Hunan Province (No. 11JJ2006).
The lead compound A8169 was modified, 12 N-hetrocyclo containing nitrogen methoxy-O-(4-aryloxy-phenyl) lactamide derivatives were designed and synthesized, and their structures were characterized by 1H NMR, 13C NMR, LC/MS and IR. The bioassay results indicated that all compounds exhibited 100% activities against Digitaria sanguinalis, Echinochloa crus-galli L and Setaria Viridis at 2250 g/ha. In particular, (R)-(+)-N-((2-chlorothiazol-5-yl)methoxy)-O-(4-((6-chloro-quinoxalin-2-yl)oxy)phenoxy) lactamide (2f) was much more effective against Digitaria sanguinalis (IC50=6.8 g/ha) and Echinochloa crus-galli (IC50=6.6 g/ha) than commercial clodinafop-propargyl and lead compound A8169.
Liu Qixing , Huang Mingzhi , Liu Aiping , Nie Siqiao , Lei Manxiang , Ren Yeguo , Pei Hui , He Liying , Hu Li , Hu Aixi . Synthesis and Herbicidal Activity of Novel N-Hetrocyclo Containing Nitrogen Methoxy-O-(4-aryloxy-phenyl) Lactamide Derivatives[J]. Chinese Journal of Organic Chemistry, 2014 , 34(1) : 118 -125 . DOI: 10.6023/cjoc201307017
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